First proof-of-concept study published in Frontiers in Bioengineering and Biotechnology

The term group at LU has published the first proof-of-concept study describing Moroxite F AB groundbreaking implant fixation technology in the journal Frontiers in Bioengineering and Biotechnology.

This peer-reviewed study demonstrates an enhanced immediate mechanical anchorage of a hip fracture fixation device to low quality osteoporotic bone both in laboratory studies as well as in a small set of patients.

Moroxite F’s tech package comprises of a method and a device for delivering hydroxyapatite particles at the interface of bone and a fracture fixation device without the use of additional pressure or complex surgical procedures, minimizing the risk of vascular leakage or complications for the patient.

Once the fixation device is placed at its final position, the HA particles reinforce the bone-implant interface and ensure an improved grip. For the sake of easing the imagination, the developed method can be considered analogous to placing a nail in a bad quality concrete wall (osteoporotic bone) vs. placing the screw in the same wall reinforced with additional cement. 

The paper further validates the developed methodology in 5 patients undergoing treatment for a hip fracture and the results demonstrate excellent spreading of the HA material at the screw threads without obvious complications.

The final part of Moroxite F’s technology comprises of biologically activating the HA particles. This is performed by sending an anti-osteoporosis drug to the HA particles post-surgery via the blood stream. Our research group, TERM at Lund University’s pre- clinical research has shown that the administered clinical research has shown that the administered osteoporosis drug seeks the HA particles and imparts a pro-bone formation effect leading to new bone formation around the implant. This concept is now being verified in a clinical study, interim results of which will be presented at the Nordic Orthopedic Federations annual meeting in Vilnius, Lithuania in April 2022. The clinical study is expected to finish in June 2023.

Reference:

A New Augmentation Method for Improved Screw Fixation in Fragile Bone. https://doi.org/10.3389/fbioe.2022.816250